I've been sitting on this post for a while, but I think now is as good a time as any to share.
I've recently started using QuickSilver on my Mac. QuickSilver is a launcher app meets Spotlight. With a short key you can open any executable file on your machine.
If you've upgraded to OSX Lion (or not) you're probably familiar with Launch Pad (if not, think of an iPad-esque style app launcher built into the OS)
Simply put: QuickSilver has nearly replaced launch pad for me in my day to day use. Just like launch pad you don't need to know where your apps are located. In fact, because it works similarly to Spotlight, you don't need to know where anything is located. You simply type the first few letters of what you're looking for and QuickSilver begins to search. Hit enter to launch. Perfect.
Additionally, QuickSilver also offers system wide short keys to launch apps. So you can very quickly launch apps and get up and running in nearly no time from a cold start. So, Command+option+T opens Twitter for me, and Command+option+G is Google Chrome etc. These are all user defined, so have at it.
If you just start typing and it can't find a file in your system, the QuickSilver window will convert to a "big text" window. So when you hit Enter, it will simply display the text you wrote nice and big across your screen until you click out. So if you need to send a message... a big message. ;-)
Anyway, if it wasn't obvious, I highly recommend you pick up QuickSilver. And the best part? It's free.